The Circadian T3 Method Supports the Adrenal Glands and Does NOT Stress Them

Does the CT3M stress the adrenal glands? This is a question that thyroid patients sometimes ask. 

The answer is a resounding NO!

The reason for this is simple. The adrenals themselves do not get fatigued, tired or stressed. They are quite simple organs and simply need cholesterol and a good ACTH signal from the pituitary gland.

The majority of cases of low cortisol (hypocortisolism or cortisol insufficiency) is due to hypothalamic-pituitary dysfunction. This is why most thyroid patients with low cortisol quite easily pass Synacthen tests (ACTH Stimulation tests). Yes, Addison's disease exists, but it is definitely does not account for the majority of cases of low cortisol.  

The HP dysfunction can be of unknown origin, probably originating from long term stress of some kind or toxicity. However, in many cases it is simply caused by low FT3 to the pituitary gland

The pituitary is known to virtually 'run on FT3'. It has the highest concentration of T3 in the body out of all tissues. It converts its own T4 to T3 using the D2 enzyme. It is easy to see why of FT3 is low within the pituitary at night that it might not be able to produce the level of ACTH that is required to drive the adrenal glands into action.

Providing more T3 is less likely to stress the pituitary and should be no stress at all on the adrenals themselves.

In some people CT3M doesn't work that well. In some it doesn't work at all. But for a great many it is very effective and brings about normal cortisol levels. 

So, in some ways it is far more likely to support the adrenal glands and it cannot stress them.

I hope this explanation helps.

Best wishes,


(Updated in January 2019)