Inconsistent Free Cortisol in Saliva and Blood Cortisol Test Results

I thought this link was pretty interesting. It goes some way to explain why sometimes we might see a contradictory result for an 8:00am morning cortisol blood test (which includes free and bound cortisol) compared to the free cortisol measured in a cortisol saliva test. Clearly, every situation is different and the entire history and situation with an individual needs to be taking into account.

The link explains that the amount of cortisol produced and the amount of free cortisol available can be very different in some scenarios. Measuring both allows for insight into the rate of cortisol clearance/metabolism. Here are two examples:

1) Higher levels of metabolized cortisol (compared to free cortisol) are often seen in obesity where adipose tissue is likely pulling cortisol from its binding protein and allowing for metabolism and clearance. The adrenal gland has to keep up with this cortisol sequestering and excretion, so cortisol production is often quite high (as seen in an 8:00am morning cortisol test or in the levels of metabolized cortisol if using the Dutch test). This insight is quite helpful for those looking to lose belly fat and suspect cortisol/stress is a major factor. These patients are often misdiagnosed as having low cortisol production when only free cortisol is measured, because high blood cortisol and low saliva cortisol is seen. Increased cortisol clearance may also be seen in hyperthyroidism and is suspected to be part of the chronic fatigue story as well. 


2)  In patients with low thyroid, the opposite pattern is often seen. When the thyroid slows down, or if there is peripheral hypothyroidism where free T3 cannot get into the cells, the clearance (or metabolism) of cortisol through the liver slows down. As a result, free cortisol starts to increase and may show up elevated. Note: this is a pattern I have seen multiple times with thyroid patients.  It is useful to know, as assuming on-going tissue-level hypothyroidism may be the best way to go forward, when low/normal blood cortisol and high saliva cortisol is seen. Simply assuming that the saliva test is correct and the blood test is not may be wrong sometimes. 

Here is the link

The bottom line is that I am a great believer in testing both free cortisol in saliva and total cortisol in blood at 8-9:00am, as you get the whole picture. Relying on free saliva cortisol only is not sensible. This position is very clear in all my books, including the latest one, The Thyroid Patient's Manual.

It is also possible that a lot of patients who have apparently high cortisol from a saliva test are being given guidance to lower the free cortisol with adaptogens, when what they really need to do is to fix the tissue hypothyroidism with more thyroid hormone. In some cases, the person might have low total cortisol (a blood test at 8 or 9:00am will show this). In this case, raising total cortisol with CT3M might also help. I think there is much misunderstanding out there still. I hope to be part of the movement to reduce misunderstanding and provide more useful information. 

I think the above is an insight worth knowing about. It also emphasises the importance of both blood and saliva testing. It at least should prompt people to think harder about the cortisol test results and question what is really going on.

A couple of other points also worth making:

A. The use of natural progesterone creams can corrupt the results in many saliva testing labs. The progesterone molecule is so similar to cortisol that many labs cannot distinguish between the two and show higher cortisol as a result. Even stopping the cream/gel a few days before might not stop this as it sits in the tissues.

B. The use of any HC cream can do the same and inflate cortisol saliva test results.

I hope that you found this article interesting and useful.

Best wishes,