Research that Supports the Circadian T3 Method (CT3M)
A friend of mine just passed me a 1978 piece of research that shows that also confirms that TSH and FT3 peak in the night.
This knowledge is important and it partly what supports my Circadian T3 Method (CT3M) optional protocol.
I have written about this in all my books, 'Recovering with T3', 'The CT3M Handbook' and my latest one 'The Thyroid Patient's Manual'.
It is called 'Circadian and 30 Minutes Variations in Serum TSH and Thyroid Hormones in Normal Subjects', by Jorgan Weeke and Hans Jorgan G. Gundersen.
This is only part of the data that supports the idea behind CT3M. The other elements being that the pituitary has the highest concentration of T3 in the body, and that it is the pituitary that begins to drive cortisol levels up in the latter part of the night. So, keeping FT3 levels up during that part of the night is important. This happens normally in healthy people, but often it does not in thyroid patients on daytime thyroid medication. Any loss of thyroid tissue (through Hashimoto's or thyroidectomy) also makes things worse as this loses a significant amount of T4 to T3 conversion capability. Any DIO1 and DIO2 gene defects might also be a big factor as they can impact conversion capability also.
Here is the link: https://eje.bioscientifica.com/view/journals/eje/89/3/acta_89_3_024.xml
(Updated in February 2019)