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Here is a 20-year observational piece of research.

It dismisses the incorrect views that T3 has adverse effects on the bones and heart! 

It confirms that T3 has no adverse effects on heart and bones. This disproves some of the major reasons that doctors use to avoid prescribing T3 - risk to the heart and to bone loss are the two most common reasons used to avoid prescribing T3 to patients, although many of us suspect that cost is the unsaid reason behind non-prescribing of T3.

We don't often see many studies concerning T3 replacement. Here is one research study that showed positive outcomes with T3 replacement when used in three doses per day (much like the Recovering with T3 protocol).

In the study hypothyroid patients were evaluated with T3 (Liothyronine) treatment dosed three times per day against T4 (Levothyroxine, Synthroid) treatment. Many measurements were taken and the T3 was more effective in resolving their hypothyroid symptoms.