Testing for DIO1 and DIO2 deiodinase enzyme gene defects

I do find it very interesting that someone with the complete set of deiodinase mutations like I have (DIO1 and DIO2 with both copies of each), can have been so well until my late twenties.

I wrote a blog post about why I ended up requiring T3-Only to get well a little while ago: http://recoveringwitht3.com/blog/why-paul-needed-t3-only-medication-update

I have spoke to thyroid researchers about this and apparently the body does find ways that are not really understood yet to compensate for the deiodinase defects.

I had no idea at all that I had any problems until my late twenties and, of course, I was taking no thyroid hormones at all until around age thirty.

I was looking through some old photos today for a different reason and it made me think of this. I found an old photo of me around age 25, and it explains to me why I have taken so long to actually test for DIO1 and DIO2. I just discounted conversion issues due to genes because I had been so well for so long. I was very fit at the time and I had always assumed that a fundamental conversion issue would have appeared very early on. I now know that this is not true and can occur later in life.

I do suggest those of you who either have a low FT3 or a high rT3 problem (or both) do get DIO1 and DIO2 tested. It can be really insightful - both in terms of just knowing the answer and in terms of guiding treatment.

23andMe raw data contains the information needed to see if there is a DIO1 defect. 

I personally used Regenerus labs to check for the DIO2 gene defect.

Other companies may provide both results, but you would need to do your own research.

I discuss the whole issue of the deiodinase defects in my new book, 'The Thyroid Patient's Manual'.

I will attach the photo. It does seem a lifetime ago now. It is about the only one I have of me just before I started to get sick.

Best wishes,

Paul