Thyroid, Histamine, Cortisol and Gut/Stomach Issues

This blog post is about my own experience with stomach acidity and how it might relate to cortisol, gut and histamine issues.

I do not pretend to be knowledgeable about digestive system issues at all. I've written this blog post simply because I felt that my own experience may offer new clues to some thyroid patients suffering similar problems.

I fully realise that when some experts read this information they will begin to make conclusions about all kinds of imbalances and insensitivities.
I'd ask these people to hang fire and read everything before forming opinions, as I have no digestive symptoms at all today and have not had any for a long time.

Not all severe issues are about gluten, grain or dairy sensitivities, or require a special kind of diet.

I hesitated before writing and publishing this information because it is not as complete and thorough as I prefer before I make it public. It is a part of my own life though and illustrates that there are many  gut - endocrine connections.

Please don't expect any kind of suggestions that come out of this. It is mostly a journey but some of it may allow the beginnings of explorations for some of you.


From the spring of 2006 to the autumn of 2010 I developed a medical problem, which caused so much pain and discomfort that I spent most of my time lying down, incapable of doing anything useful. This problem also delayed the writing of my book 'Recovering with T3'.

In 2006 I developed high level of stomach acid and abdominal pain that became so severe I found myself in the Accident and Emergency (E.R.) department of a hospital.

After eating any meal, my stomach would swell up within 30 minutes of the meal, and then it would suddenly release its contents and I could feel the rush of liquid as my stomach released excessive amounts of acid. The following few hours were agony and left me on the floor in pain. 

I was placed on very high levels of pain relief, acid suppressants and eventually other symptoms developed. 

My doctors were completely confused and I began to do a lot of investigation myself. I eventually suspected that histamine was at the heart of my issues. An immunologist appeared to confirm this diagnosis.

He increased my anti-histamine medication and this helped considerably.

In the process of resolving this health issue I found information that suggests strong links between thyroid disease and issues with food allergies, sensitivities and histamine problems.

However, although there may have been a histamine connection, this was not the entire story.

I am posting this because it is just possible that someone may find something of use in it.

Articles I've Written About This Problem

I wrote two articles about this but be aware I have since gone further than the information in either of the articles. I am leaving them here in this blog post, as they still have some useful information. They just were not the final story on what was causing my problem. Here is the information on the articles:

1. I wrote a short article on my experience which was published in the Spring 2012 'Focus' magazine. 'Focus' is the newsletter of Allergy UK (the UK's leading medical charity dealing with allergy, food intolerance and chemical sensitivity). I also have a link to a PDF of this magazine - click here to open the PDF. 

2. The second and much longer article (30 pages or so) is a full  write up of this issue, which includes much more information. Please click here to read this longer PDF file.

Cortisol - the Final Piece of the Puzzle

I have now been using the Circadian T3 Method for about 20 years. CT3M gave me my life back by improving my cortisol levels so that I could live normally again.

In the spring of 2012 I did a 24-hour cortisol saliva test and discovered that for the first time my cortisol levels were high during the day, with the morning and noon cortisol samples raised above the top limits of the reference ranges. I therefore modified my CT3M dose in order to lower my cortisol levels, i.e. I moved the circadian dose forward in time. 

I subsequently discovered that I was able to slowly wean my anti-histamine levels to the point that I no longer need them. 

This means that high cortisol was definitely a factor in my problems.

High cortisol is known to increase stomach acidity. How much of my problem was some underlying histamine issue and how much was simply due to high cortisol I cannot say.

However, it is fairly clear that elevated cortisol raised stomach acidity and this caused the majority of the problem..

I have had no repeat instance of the problem since then.

However, it is clear that CT3M has continued to improve my cortisol response over the years, and that the CT3M really works.

I hope this may have helped some of you.

Best wishes,


(Updated in February 2019)