Thyroid, Histamine, Cortisol and Gut/Stomach Issues

This blog post is about my own experience with stomach acidity, gut and histamine issues.

I do not pretend to be knowledgeable about digestive system issues at all. I've written this blog post simply because I felt that my own experience may offer some beginnings of new clues to some thyroid patients suffering similar problems.

I fully realise that when some experts read this information they will begin to make conclusions about all kinds of imbalances and insensitivities. I'd ask these people to hang fire and read everything before forming opinions as I have no digestive symptoms at all today and have not had any for a long time. Not everything is about gluten and dairy sensitivities, although gluten can be a problem for some people.

I hesitated before writing and publishing this information because it is not as complete and thorough as I like to have information before I make it public. It is a part of my own life though and illustrates that there are many  gut - endocrine connections.

Please don't expect any kind of suggestions that come out of this. It is mostly a journey but some of it may allow the beginnings of explorations for some of you.


From the spring of 2006 to the autumn of 2010 I developed a medical problem, which caused so much pain and discomfort that I spent most of my time lying down, incapable of doing anything useful. This problem also delayed the writing of my book 'Recovering with T3'.

In 2006 I developed high level of stomach acid and abdominal pain that became so severe I found myself in the Accident and Emergency (E.R.) department of a hospital. I was placed on very high levels of pain relief, acid suppressants and eventually other symptoms developed.

My doctors were completely confused and I had to do a lot of investigation myself. I eventually proved that histamine was at the heart of my issues. An immunologist confirmed this diagnosis.

In the process of resolving this health issue I found information that suggests strong links between thyroid disease and issues with food allergies, sensitivities and histamine problems.

I am posting this because it is just possible that someone may find something of use in it.

Articles I've Written About This Problem

I wrote two articles about this:

1. I wrote a short article on my experience which was published in the Spring 2012 'Focus' magazine. 'Focus' is the newsletter of Allergy UK (the UK's leading medical charity dealing with allergy, food intolerance and chemical sensitivity). I also have a link to a PDF of this magazine - click here to open the PDF.  This article may also be found via the link: and then the 'Food Allergy & Intolerance Week Special' must be downloaded.

2. The second and much longer article (30 pages or so) is a full  write up of this issue, which includes much more information. Please click here to read this longer PDF file.


I have been using the Circadian T3 Method for nearly 15 years. The CT3M gave me my life back by improving my adrenal function so that I could live normally again.

In the spring of 2012 I did a 24-hour adrenal saliva test and discovered that for the first time my cortisol levels were high during the day, with the morning and noon cortisol samples raised above the top limits of the reference ranges. I therefore modified my circadian dose of T3 medication to lower my cortisol levels, i.e. I moved the circadian dose forward in time. 

I subsequently discovered that I was able to slowly wean my anti-histamine levels to the point that I no longer need them. 

This means that high cortisol was definitely a factor in my problems. High cortisol is known to increase stomach acidity. How much of my problem is some underlying issue with urticaria and how much was simply due to cortisol I cannot say. However, I suspect the elevated cortisol raised stomach acidity and this resulted in irritation and inflamation in my gut. Perhaps it was urticaria that was induced that caused the increase in histamine levels and perhaps it was just as a result of increased acidity.

Much more time will need to elapse before I can say with confidence that this problem has completely gone away without the use of antihistamines. As ever I am quite a sceptic - it will take a lot of data to convince me that I am completely over this without antihistamines.

However, it is clear that my adrenal performance has continued to improve over the years and that the CT3M really works. The CT3M has continued to help my adrenals to regain their ability and that my adrenals can even produce high cortisol over the entire day now. These elevated cortisol levels had a part to play in my four very difficult years of stomach/gut problems.

Allergy UK

These are a few resources that I have information on that may be of value. I have made no attempt to compile a comprehensive set - I am merely documenting the information I already have.

Allergy UK:
Allergy UK is the UK's leading medical charity dealing with allergy, food intolerance and chemical sensitivity. Allergy UK has its own website:

Allergy UK also have a dedicated helpline, manned by a team of fully trained allergy advisors, providing invaluable support and information for sufferers of allergy, intolerance and sensitivities.

Allergy UK also has a forum, which is a meeting place for patients with allergies, sensitivities, histamine problems and other related issues:

Useful Websites


"Dangerous Grains" by James Braly, MD and Ron Hoggan, MA

"Healthier Without Wheat" by Dr. Stephen Wangen

"Gut and Psychology Syndrome" by Natasha Campbell McBride

"Wheat Belly" by William Davis, MD.


I hope some of you may have found something of use here.

Best wishes,