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Higher cortisol levels reduce TSH (through the effect on the hypothalamic-pituitary system), and this reduces T4 to T3 conversion. Lower cortisol levels increase TSH. resulting in an increase in T4 to T3 conversion. Studies have found that in severe cortisol deficiency, the TSH and FT3 are often high. Cortisol (HC) supplementation in these people, normalises the TSH and FT3.

The D1 and D2 deiodinase enzymes are produced in our cells to enable the conversion of FT4 to FT3 to occur within our cells. Both enzymes are seleno-proteins, i.e. they have selenium as part of their structure. Hence, if someone has low levels of selenium this can hamper conversion. Many thyroid patients take 100 or 200 mcg of selenium supplement per day to ensure they have sufficient.

There is a new Facebook group. It is called 'The Thyroid Patient's Manual'.

The idea behind the group is to provide a safe environment for members to ask Paul Robinson questions that relate to the new book 'The Thyroid Patient's Manual', as well as questions relating to his other two books, 'Recovering with T3' and 'The CT3M Handbook'.

This is a bit of a different blog post for me.

I normally do technical ones, but this is different. 

We have an insidious, creeping, badly-managed and abusive situation going on within the UK right now.

It is not dissimilar to what is happening in some other countries. 

Thyroid patients who have been well using T3, either in combination with T4 (Synthroid) are having their T3 medication withdrawn.